1597438-86-2
Chemical Structure
BRD1172
Synonym(s): ML320
- CAS No.: 1597438-86-2
- Formula:C20H20F3N3O2
- Molecular Weight:391.39
IUPAC Name: (R)-4-(2-methoxyphenyl)-7,7-dimethyl-3-(trifluoromethyl)-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one
InChIKey: YWMJEKUKEKXNSA-CQSZACIVSA-N
SMILES: FC(F)(C1=C2[C@H](C3=C(C=CC=C3)OC)C4=C(CC(C)(CC4=O)C)NC2=NN1)F
Biological Activity: BRD1172 (ML320) is a selectivity GSK3β inhibitor with an IC50 of 24 nM for GSK3β over CDK5. BRD1172 significantly inhibits GSK3β-mediated Tau phosphorylation in SH-SY5Y cells, and relieves negative regulation by GSK3β on β-catenin degradation and TCF/LEF promoter activities. BRD1172 can be used for Alzheimer’s disease, cardiac hypertrophy and cancers research[1].
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BRD1172 | BRD1172 (ML320) is a selectivity GSK3β inhibitor with an IC50 of 24 nM for GSK3β over CDK5. BRD1172 significantly inhibits GSK3β-mediated Tau phosphorylation in SH-SY5Y cells, and relieves negative regulation by GSK3β on β-catenin degradation and TCF/LEF promoter activities. BRD1172 can be used for Alzheimer’s disease, cardiac hypertrophy and cancers research. | |||||||||||||||||||||
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Keywords
