161099-37-2
Chemical Structure
Glicoricone
- CAS No.: 161099-37-2
- Formula:C21H20O6
- Molecular Weight:368.38
IUPAC Name: 3-(4,6-dihydroxy-2-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)-7-hydroxy-4H-chromen-4-one
InChIKey: SSDIPYMSXRNGMZ-UHFFFAOYSA-N
SMILES: O=C1C(C2=C(O)C=C(O)C(C/C=C(C)\C)=C2OC)=COC3=CC(O)=CC=C13
Biological Activity: Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC50 of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity[1][2].
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Glicoricone | 96.0% | Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC50 of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity. | ||||||||||||||||||||
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- [1]. Hatano T, et, al. Phenolic constituents of licorice. III. Structures of glicoricone and licofuranone, and inhibitory effects of licorice constituents on monoamine oxidase. Chem Pharm Bull (Tokyo). 1991 May;39(5):1238-43. [Content Brief]
- [2]. Boonmuen N, et, al. Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities. Steroids. 2016 Jan;105:42-9. [Content Brief]
Keywords