1628208-23-0
1628208-23-0
Chemical Structure
CPI-455
- CAS No.: 1628208-23-0
- Formula:C16H14N4O
- Molecular Weight:278.31
IUPAC Name: 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
InChIKey: DHXKRMSKXLDZGY-UHFFFAOYSA-N
SMILES: N#CC1=C2NC(C3=CC=CC=C3)=C(C(C)C)C(N2N=C1)=O
Biological Activity: CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CPI-455 | 98.17% | CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents. | ||||||||||||||||||||
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CPI-455 (Standard) | ≥98% | CPI-455 (Standard) is the analytical standard of CPI-455 (HY-100421). This product is intended for research and analytical applications. CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents. | ||||||||||||||||||||
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References
Keywords
