1628858-03-6
Chemical Structure
Pafolacianine tetrasodium
Synonym(s): OTL 38 tetrasodium
- CAS No.: 1628858-03-6
- Formula:C61H63N9Na4O17S4
- Molecular Weight:1414.42
IUPAC Name: sodium (S)-2-(4-(((2-amino-4-oxo-4,8-dihydropteridin-6-yl)methyl)amino)benzamido)-3-(4-(((Z)-2-((Z)-2-(3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)-3H-indol-1-ium-2-yl)vinyl)-6-(2-((Z)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)oxy)phenyl)propanoate
InChIKey: LRVBSDMJFVZFHH-NFVAJSDSSA-J
SMILES: O=S(CCCCN1C2=CC=C(S(=O)(O[Na])=O)C=C2C(C)(/C1=C/C=C3C(OC4=CC=C(C=C4)C[C@@H](C(O[Na])=O)NC(C5=CC=C(C=C5)NCC(N=C67)=CNC6=NC(N)=NC7=O)=O)=C(CCC\3)/C=C\C8=[N+](C9=CC=C(S(=O)([O-])=O)C=C9C8(C)C)CCCCS(=O)(O[Na])=O)C)(O[Na])=O
Biological Activity: Pafolacianine tetrasodium (OTL 38 tetrasodium) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine tetrasodium excites at 774 to 775 nm and emits at 794 to 796 nm[1][2][3].
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Pafolacianine tetrasodium | Pafolacianine tetrasodium (OTL 38 tetrasodium) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine tetrasodium excites at 774 to 775 nm and emits at 794 to 796 nm. | |||||||||||||||||||||
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References
- [1]. Jane J Keating, et, al. Intraoperative near-infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large-animal model. Cancer. 2017 May 15;123(6):1051-1060. [Content Brief]
- [2]. Gul Z, et al. Pafolacianine, the magic wand of intraoperative imaging of folate-receptor positive ovarian cancer. Ann Transl Med. 2023 Oct 25;11(11):394. [Content Brief]
- [3]. Ishiwata T, et al. Transbronchial real-time lung tumor localization with folate receptor-targeted near-infrared molecular imaging: A proof of concept study in animal models. J Thorac Cardiovasc Surg. 2023 Jun;165(6):e240-e251. [Content Brief]
