1639220-19-1
1639220-19-1
Chemical Structure
Sigma-1 receptor antagonist 1
- CAS No.: 1639220-19-1
- Formula:C19H23Cl2N3O
- Molecular Weight:380.31
IUPAC Name: 5-chloro-2-(4-chlorophenyl)-4-methyl-6-(3-(piperidin-1-yl)propoxy)pyrimidine
InChIKey: MSFUOAXHQLXDAO-UHFFFAOYSA-N
SMILES: CC1=NC(C2=CC=C(Cl)C=C2)=NC(OCCCN3CCCCC3)=C1Cl
Biological Activity: Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain[1].
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Sigma-1 receptor antagonist 1 | 98.96% | Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain. | ||||||||||||||||||||
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References
Keywords
