Sigma-1 receptor antagonist 1
Based on 1 Customer Validation
Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain.
For research use only. We do not sell to patients.
- Purity: 98.96%
- CAS No.: 1639220-19-1
- Formula: C19H23Cl2N3O
- Molecular Weight:380.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Sigma Receptor Isoforms
More
Biological Activity
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Sigma 1 Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
6.98 μM
Compound: 137
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Inhibition of ERG channel in HEK293 cells by whole cell patch clamp technique
Inhibition of ERG channel in HEK293 cells by whole cell patch clamp technique
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[PMID: 25420090] |
| HEK293 | IC50 |
6.98 μmol
Compound: 137
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Inhibition of ERG channel in HEK293 cells by whole cell patch clamp technique
Inhibition of ERG channel in HEK293 cells by whole cell patch clamp technique
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[PMID: 25420090] |
Sigma?1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor (Ki = 1.06 nM) and good σ-1/2 selectivity (1344-fold)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1639220-19-1
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Appearance Solid
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Molecular Weight 380.31
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Formula C19H23Cl2N3O
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Color Light yellow to yellow
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SMILES
CC1=NC(C2=CC=C(Cl)C=C2)=NC(OCCCN3CCCCC3)=C1Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 6.25 mg/mL (16.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6294 mL | 13.1472 mL | 26.2943 mL | 65.7358 mL |
| 5 mM | 0.5259 mL | 2.6294 mL | 5.2589 mL | 13.1472 mL | |
| 10 mM | 0.2629 mL | 1.3147 mL | 2.6294 mL | 6.5736 mL | |
| 15 mM | 0.1753 mL | 0.8765 mL | 1.7530 mL | 4.3824 mL |
Sigma-1 receptor antagonist 1 Related Classifications
HY-125821 Related Classifications
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