1639358-50-1
Chemical Structure
CBB3001
- CAS No.: 1639358-50-1
- Formula:C19H27NO5
- Molecular Weight:349.43
IUPAC Name: tert-butyl ((1R,2S)-2-(4-((tert-butoxycarbonyl)oxy)phenyl)cyclopropyl)carbamate
InChIKey: VVFYDJJSFHIMKO-LSDHHAIUSA-N
SMILES: N(C(OC(C)(C)C)=O)[C@H]1[C@@H](C1)C2=CC=C(OC(OC(C)(C)C)=O)C=C2
Biological Activity: CBB3001 is an inhibitor of LSD1/KDM1A. CBB3001 exerts its effect by inhibiting Histone Demethylase activity, with an IC50 of 21.25 μM. It downregulates the expression of pluripotency-related proteins and genes such as SOX2 and OCT4, and induces cell differentiation, growth arrest, and apoptosis. CBB3001 can be used for research on testicular germ cell tumors, teratomas, and embryonal carcinomas[1][2][3][4][5][6][7].
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CBB3001 | CBB3001 is an inhibitor of LSD1/KDM1A. CBB3001 exerts its effect by inhibiting Histone Demethylase activity, with an IC50 of 21.25 μM. It downregulates the expression of pluripotency-related proteins and genes such as SOX2 and OCT4, and induces cell differentiation, growth arrest, and apoptosis. CBB3001 can be used for research on testicular germ cell tumors, teratomas, and embryonal carcinomas. | |||||||||||||||||||||
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References
- [1]. Tong D, et al. The emerging roles of histone demethylases in cancers. Cancer metastasis reviews. 2024 Jun;43(2):795-821.
- [2]. Hoang N, et al. New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. Bioorganic & medicinal chemistry. 2018 May 01;26(8):1523-1537.
- [3]. Jostes S, et al. Epigenetic drugs and their molecular targets in testicular germ cell tumours. Nature reviews. Urology. 2019 Apr;16(4):245-259.
- [4]. Guo P, et al. A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. eLife. 2024 Feb 12;13:e86168.
- [5]. Guo P, et al. The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis. Nature communications. 2022 Nov 05;13(1):6696.
- [6]. Marroncelli N, et al. Is Human Chorionic Gonadotropin a Reliable Marker for Testicular Germ Cell Tumor? New Perspectives for a More Accurate Diagnosis. Cancers. 2025 Jul 21;17(14):2409.
