1646361-04-7
1646361-04-7
Chemical Structure
Morphothiadin mesylate
Synonym(s): GLS4 mesylate
- CAS No.: 1646361-04-7
- Formula:C22H26BrFN4O6S2
- Molecular Weight:605.50
InChIKey: FDMKMKYZDJHHFM-UHFFFAOYSA-N
SMILES: O=C(C1=C(CN2CCOCC2)N=C(C3=NC=CS3)NC1C4=CC=C(C=C4Br)F)OCC.O=S(O)(C)=O
Biological Activity: Morphothiadin (GLS4) mesylate is a potent inhibitor of wild-type and Adefovir (HY-B1826)-resistant HBV replication with an IC50 value of 12 nM[1][2].
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Morphothiadin mesylate | Morphothiadin (GLS4) mesylate is a potent inhibitor of wild-type and Adefovir (HY-B1826)-resistant HBV replication with an IC50 value of 12 nM. | |||||||||||||||||||||
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References
- [1]. Zhou X, et al. Effects of ketoconazole and rifampicin on the pharmacokinetics of GLS4, a novel anti-hepatitis B virus compound, in dogs. Acta Pharmacol Sin. 2013 Nov;34(11):1420-6. [Content Brief]
- [2]. Wu G, et al. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly. Antimicrob Agents Chemother. 2013 Nov;57(11):5344-54. [Content Brief]
Keywords
