165250-47-5
165250-47-5
Chemical Structure
BMS-181885
- CAS No.: 165250-47-5
- Formula:C25H28N6O3
- Molecular Weight:460.53
IUPAC Name: 3-((3-(3-(4-(5-methoxypyrimidin-4-yl)piperazin-1-yl)propyl)-1H-indol-5-yl)amino)-4-methylcyclobut-3-ene-1,2-dione
InChIKey: HCXROGVQIBVJTA-UHFFFAOYSA-N
SMILES: O=C1C(C(NC2=CC3=C(NC=C3CCCN4CCN(C5=NC=NC=C5OC)CC4)C=C2)=C1C)=O
Biological Activity: BMS-181885 is a selective 5-HT1 receptor agonist and a ligand for 5-HT1B/1D receptors. BMS-181885 exhibits anti-migraine activity. BMS-181885 can be used in the research of neurological diseases such as migraine[1][2][3].
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BMS-181885 | BMS-181885 is a selective 5-HT1 receptor agonist and a ligand for 5-HT1B/1D receptors. BMS-181885 exhibits anti-migraine activity. BMS-181885 can be used in the research of neurological diseases such as migraine. | |||||||||||||||||||||
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References
- [1]. Srinivas NR, et al. Absolute bioavailability and dose proportionality of BMS-181885, an antimigraine agent, following the administration of single intranasal doses to cynomolgus monkeys. J Pharm Sci. 1998 Sep;87(9):1170-2. [Content Brief]
- [2]. Schulze G E, et al. Intranasal toxicity of BMS-181885, a novel 5-HT1 agonist. International journal of toxicology, 1999, 18(5): 285-296.
- [3]. Saxena PR, et al. BMS-181885, a 5-HT1B/1D receptor ligand, in experimental models predictive of antimigraine activity and coronary side-effect potential. Eur J Pharmacol. 1998 Jun 26;351(3):329-39. [Content Brief]
Keywords
