166967-84-6
Chemical Structure
NTE-122 dihydrochloride
- CAS No.: 166967-84-6
- Formula:C38H60Cl2N6O2
- Molecular Weight:703.83
IUPAC Name: 1,1'-(((1r,4r)-cyclohexane-1,4-diyl)bis(methylene))bis(1-cyclohexyl-3-(4-(dimethylamino)phenyl)urea) dihydrochloride
InChIKey: RJZJTTNFFARMHQ-LFZHATSCSA-N
SMILES: CN(C)C(C=C1)=CC=C1NC(N(C2CCCCC2)C[C@@H](CC3)CC[C@H]3CN(C4CCCCC4)C(NC5=CC=C(C=C5)N(C)C)=O)=O.Cl.Cl
Biological Activity: NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with the IC50 in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis[1].
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NTE-122 dihydrochloride | NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with the IC50 in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis. | |||||||||||||||||||||
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Keywords
