1684398-38-6
Chemical Structure
Mono(2-ethyl-5-hydroxyhexyl) terephthalate
Synonym(s): MEHHTP
- CAS No.: 1684398-38-6
- Formula:C16H22O5
- Molecular Weight:294.34
IUPAC Name: 4-(((2-ethyl-5-hydroxyhexyl)oxy)carbonyl)benzoic acid
InChIKey: ODRKAFOVPBFSIN-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(O)=O)C=C1)OCC(CC)CCC(O)C
Biological Activity: Mono (2-ethyl-5-hydroxyhexyl) terephthalate (MEHHTP), a hydroxyl metabolite of the phthalate alternative Di-2-ethylhexyl terephthalate (DEHTP), is a liver X receptor α (LXRα) agonist with a binding energy of -7.41 kcal/mol. Mono (2-ethyl-5-hydroxyhexyl) terephthalate upregulates LXRα downstream targets such as SREBP-1c and FASN and increases lipogenic enzyme activity in hepatocytes, and elevating triglyceride (TG) levels. Mono (2-ethyl-5-hydroxyhexyl) terephthalate is promising for research of nonalcoholic fatty liver disease (NAFLD)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mono(2-ethyl-5-hydroxyhexyl) terephthalate | 98.27% | Mono (2-ethyl-5-hydroxyhexyl) terephthalate (MEHHTP), a hydroxyl metabolite of the phthalate alternative Di-2-ethylhexyl terephthalate (DEHTP), is a liver X receptor α (LXRα) agonist with a binding energy of -7.41 kcal/mol. Mono (2-ethyl-5-hydroxyhexyl) terephthalate upregulates LXRα downstream targets such as SREBP-1c and FASN and increases lipogenic enzyme activity in hepatocytes, and elevating triglyceride (TG) levels. Mono (2-ethyl-5-hydroxyhexyl) terephthalate is promising for research of nonalcoholic fatty liver disease (NAFLD). | ||||||||||||||||||||
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