169454-13-1
Chemical Structure
BODi-1
- CAS No.: 169454-13-1
- Formula:C41H54I4N6S2
- Molecular Weight:1202.66
InChIKey: TYBKADJAOBUHAD-UHFFFAOYSA-J
SMILES: C[N+]1=C(/C=C2C=CN(CCC[N+](C)(C)CCC[N+](C)(C)CCCN3C=C/C(C=C3)=C\C4=[N+](C)C5=C(C=CC=C5)S4)C=C\2)SC6=C1C=CC=C6.[I-].[I-].[I-].[I-]
Biological Activity: BODi-1 is a fluorescent modulator targeting dsDNA, which binds to dsDNA via a bis-intercalation mechanism (Ex=465 nm, Em=490 nm). BODi-1 exhibits a fluorescence enhancement effect upon binding to nucleic acids, but its fluorescence intensity, anisotropy and average lifetime decrease at higher dye/DNA ratios. When BODi-1 binds to DNA in liposome complexes, it also shows red-shifted emission spectra, along with reduced quantum yield and average lifetime. BODi-1 does not induce significant DNA conformational changes when the dye/DNA ratio is below 0.01. BODi-1 can be used as a fluorescent probe for the characterization of liposome complexes and FRET studies at this ratio[1].
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BODi-1 | BODi-1 is a fluorescent modulator targeting dsDNA, which binds to dsDNA via a bis-intercalation mechanism (Ex=465 nm, Em=490 nm). BODi-1 exhibits a fluorescence enhancement effect upon binding to nucleic acids, but its fluorescence intensity, anisotropy and average lifetime decrease at higher dye/DNA ratios. When BODi-1 binds to DNA in liposome complexes, it also shows red-shifted emission spectra, along with reduced quantum yield and average lifetime. BODi-1 does not induce significant DNA conformational changes when the dye/DNA ratio is below 0.01. BODi-1 can be used as a fluorescent probe for the characterization of liposome complexes and FRET studies at this ratio. | |||||||||||||||||||||
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Keywords
