173043-84-0
Chemical Structure
3,4-Dephostatin
Synonym(s): Methyl-3,4-dephostatin
- CAS No.: 173043-84-0
- Formula:C7H8N2O3
- Molecular Weight:168.15
IUPAC Name: N-(3,4-dihydroxyphenyl)-N-methylnitrous amide
InChIKey: XAKAQCMEMMZUEO-UHFFFAOYSA-N
SMILES: OC1=CC=C(N(C)N=O)C=C1O
Biological Activity: 3,4-Dephostatin (Methyl-3,4-dephostatin) is an inhibitor of protein-tyrosine phosphatase (PTPase). 3,4-Dephostatin accelerates nerve growth factor (NGF)-induced neurite formation in PC12h cells. 3,4-Dephostatin sustains the NGF-induced tyrosine phosphorylation of proteins, most prominently that of mitogen-activated protein (MAP) kinase. 3,4-Dephostatin also prolongs epidermal growth factor (EGF)-induced tyrosine phosphorylation and activation of MAP kinase[1].
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3,4-Dephostatin | 3,4-Dephostatin (Methyl-3,4-dephostatin) is an inhibitor of protein-tyrosine phosphatase (PTPase). 3,4-Dephostatin accelerates nerve growth factor (NGF)-induced neurite formation in PC12h cells. 3,4-Dephostatin sustains the NGF-induced tyrosine phosphorylation of proteins, most prominently that of mitogen-activated protein (MAP) kinase. 3,4-Dephostatin also prolongs epidermal growth factor (EGF)-induced tyrosine phosphorylation and activation of MAP kinase. | |||||||||||||||||||||
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Keywords
