178925-48-9
Chemical Structure
5’-O-DMTr-5-iodo-2’-dU-3’-CED phosphoramidite
- CAS No.: 178925-48-9
- Formula:C39H46IN4O8P
- Molecular Weight:856.68
IUPAC Name: (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChIKey: TVIUERSZLNUGGY-QMTPQUJBSA-N
SMILES: O=C(N1[C@H](O2)C[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]2COC(C3=CC=C(C=C3)OC)(C4=CC=CC=C4)C5=CC=C(C=C5)OC)NC(C(I)=C1)=O
Biological Activity: 5’-O-DMTr-5-iodo-2’-dU-3’-CED phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
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5’-O-DMTr-5-iodo-2’-dU-3’-CED phosphoramidite | 5’-O-DMTr-5-iodo-2’-dU-3’-CED phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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