1793050-70-0
Chemical Structure
(R)-Gyramide A hydrochloride
- CAS. Nr.: 1793050-70-0
- Formula:C21H28ClFN2O3S
- Molecular Weight:442.98
IUPAC Name: (R)-5-fluoro-N-(1-(4-isopropoxybenzyl)pyrrolidin-3-yl)-2-methylbenzenesulfonamide hydrochloride
InChIKey: LLHBXQVGBTVEDP-FSRHSHDFSA-N
SMILES: O=S(C1=CC(F)=CC=C1C)(N[C@H]2CN(CC3=CC=C(OC(C)C)C=C3)CC2)=O.[H]Cl
Biological Activity: (R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.
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(R)-Gyramide A hydrochloride | (R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV. | |||||||||||||||||||||
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Keywords
