1802908-05-9
Chemical Structure
Methyltetrazine-PEG4-amine
- CAS No.: 1802908-05-9
- Formula:C17H25N5O4
- Molecular Weight:363.41
IUPAC Name: 2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethan-1-amine
InChIKey: JOEAATMYJGXMGS-UHFFFAOYSA-N
SMILES: CC1=NN=C(C2=CC=C(OCCOCCOCCOCCN)C=C2)N=N1
Biological Activity: Methyltetrazine-PEG4-amine is a linker for antibody-drug conjugates and a click chemistry reagent that can be used for the synthesis of ADCs. Methyltetrazine-PEG4-amine can be used to synthesize click-active albumin-binding radioligands as well as VLA-4-targeted radiopharmaceutical precursors. Methyltetrazine-PEG4-amine is applicable to research related to prostate cancer[1][2][3].
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Methyltetrazine-PEG4-amine | Methyltetrazine-PEG4-amine is a linker for antibody-drug conjugates and a click chemistry reagent that can be used for the synthesis of ADCs. Methyltetrazine-PEG4-amine can be used to synthesize click-active albumin-binding radioligands as well as VLA-4-targeted radiopharmaceutical precursors. Methyltetrazine-PEG4-amine is applicable to research related to prostate cancer. | |||||||||||||||||||||
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References
- [1]. He X, et al. Affinity-Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics. Advanced healthcare materials. 2026 Aug;15(29):e71385.
- [2]. Li, Longbo, et al. Effect of Click Chemistry Linkages on the Biological Behavior of Albumin-Binding 177Lu-DOTAGA-pIBA-LLP2A Analogues Targeting Melanoma. Bioconjugate Chemistry 36.9 (2025): 2002-2012.
- [3]. Muraki M, et al. Site-specific chemical conjugation of human Fas ligand extracellular domain using trans-cyclooctene - methyltetrazine reactions. BMC biotechnology. 2017 Jul 03;17(1):56. [Content Brief]
