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Cat. No.: HY-141261

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Methyltetrazine-PEG4-amine

Methyltetrazine-PEG4-amine is a linker for antibody-drug conjugates and a click chemistry reagent that can be used for the synthesis of ADCs. Methyltetrazine-PEG4-amine can be used to synthesize click-active albumin-binding radioligands as well as VLA-4-targeted radiopharmaceutical precursors. Methyltetrazine-PEG4-amine is applicable to research related to prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 1802908-05-9
Formula: C₁₇H₂₅N₅O₄
Molecular Weight:363.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Methyltetrazine-PEG4-amine Chemical Structure

CAS No.: 1802908-05-9

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All ADC Linkers Isoforms :

In Vitro

Methyltetrazine-PEG4-amine hydrochloride is a bifunctional linker commonly used in bioorthogonal labeling and antibody-drug conjugates (ADCs). Methyltetrazine-PEG4-amine hydrochloride consists of four functional moieties: the methyltetrazine group with catalyst-free ultrafast click chemistry activity, PEG4 which enhances water solubility and flexibility while reducing steric hindrance, an amine group with amide coupling activity, and hydrochloride which improves the storage and transportation stability of the overall reagent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1802908-05-9
Molecular Weight 363.41
Formula C₁₇H₂₅N₅O₄
SMILES

CC1=NN=C(C2=CC=C(OCCOCCOCCOCCN)C=C2)N=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He X, et al. Affinity-Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics. Advanced healthcare materials. 2026 Aug;15(29):e71385.

[2]. Li, Longbo, et al. Effect of Click Chemistry Linkages on the Biological Behavior of Albumin-Binding 177Lu-DOTAGA-pIBA-LLP2A Analogues Targeting Melanoma. Bioconjugate Chemistry 36.9 (2025): 2002-2012.

[3]. Muraki M, et al. Site-specific chemical conjugation of human Fas ligand extracellular domain using trans-cyclooctene - methyltetrazine reactions. BMC biotechnology. 2017 Jul 03;17(1):56. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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