1821038-80-5
Chemical Structure
PI3Kγ inhibitor 4
- CAS No.: 1821038-80-5
- Formula:C20H24N4O4S
- Molecular Weight:416.49
IUPAC Name: 3-(6-amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-(2-hydroxy-2-methylpropyl)-4-methylbenzenesulfonamide
InChIKey: UQIUWUJYJBQZBY-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C)C(C2=CC(C3=CN=C(C)O3)=C(N)N=C2)=C1)(NCC(C)(O)C)=O
Biological Activity: PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC50 of 40 nM. PI3Kγ inhibitor 4 shows ∼7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation[1].
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PI3Kγ inhibitor 4 | PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC50 of 40 nM. PI3Kγ inhibitor 4 shows ∼7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation. | |||||||||||||||||||||
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Keywords
