1826116-38-4
Chemical Structure
SLMP53-2
- CAS No.: 1826116-38-4
- Formula:C26H22N2O2
- Molecular Weight:394.47
IUPAC Name: (3S,9bR)-3-((1-methyl-1H-indol-3-yl)methyl)-9b-phenyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one
InChIKey: PEHYINMYYPHEER-RXFWQSSRSA-N
SMILES: O=C1C2=CC=CC=C2[C@](OC3)(C4=CC=CC=C4)N1[C@H]3CC5=CN(C)C6=CC=CC=C56
Biological Activity: SLMP53-2 is a mutant p53 reactivator. SLMP53-2 restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with the Hsp70, leading to the reestablishment of p53 transcriptional activity. SLMP53-2 can induce cell cycle arrest, apoptosis and endoplasmic reticulum (ER) stress. SLMP53-2 exhibits antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SLMP53-2 | 99.96% | SLMP53-2 is a mutant p53 reactivator. SLMP53-2 restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with the Hsp70, leading to the reestablishment of p53 transcriptional activity. SLMP53-2 can induce cell cycle arrest, apoptosis and endoplasmic reticulum (ER) stress. SLMP53-2 exhibits antitumor activity. | ||||||||||||||||||||
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- [1]. Gomes S, et, al. SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. Cancers (Basel). 2019 Aug 10;11(8):1151. [Content Brief]
- [2]. Loureiro JB, et, al. Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis. Pharmacol Res. 2022 Jan;175:106026. [Content Brief]
Keywords
