184025-18-1
184025-18-1
Chemical Structure
Ciproxifan
Synonym(s): FUB-359
- CAS No.: 184025-18-1
- Formula:C16H18N2O2
- Molecular Weight:270.33
IUPAC Name: (4-(3-(1H-imidazol-5-yl)propoxy)phenyl)(cyclopropyl)methanone
InChIKey: ACQBHJXEAYTHCY-UHFFFAOYSA-N
SMILES: O=C(C1CC1)C(C=C2)=CC=C2OCCCC3=CN=CN3
Biological Activity: Ciproxifan (FUB 359) is a potent, selective, orally bioavailable and competitive antagonist of histamine H3-receptor, with an IC50 of 9.2 nM. Ciproxifan displays low apparent affinity at other receptor subtypes. Ciproxifan can be used for the research of aging disorders and Alzheimer's disease[1][3].
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Ciproxifan | 99.26% | Ciproxifan (FUB 359) is a potent, selective, orally bioavailable and competitive antagonist of histamine H3-receptor, with an IC50 of 9.2 nM. Ciproxifan displays low apparent affinity at other receptor subtypes. Ciproxifan can be used for the research of aging disorders and Alzheimer's disease. | ||||||||||||||||||||
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References
- [1]. Ligneau X, et, al. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther. 1998 Nov;287(2):658-66. [Content Brief]
- [3]. Bardgett ME, et al. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72. [Content Brief]
Keywords
