1845688-96-1
Chemical Structure
5N-Bicalutamide
- CAS No.: 1845688-96-1
- Formula:C17H13F4N3O4S
- Molecular Weight:431.36
IUPAC Name: N-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide
InChIKey: JWQMHMGGGRQTSY-UHFFFAOYSA-N
SMILES: N#CC1=NC=C(C=C1C(F)(F)F)NC(=O)C(O)(C)CS(=O)(=O)C2=CC=C(F)C=C2
Biological Activity: 5N-Bicalutamide is an androgen receptor (AR) antagonist with a Ki of 0.15 nM. 5N-Bicalutamide is a derivative of Bicalutamide (HY-14249). 5N-Bicalutamide reacts with Cys784 in the AR binding pocket via an activated aryl nitrile group to form a reversible thioimidate covalent adduct, which significantly enhances its binding affinity and inhibitory potency. 5N-Bicalutamide is used in prostate cancer-related research[1].
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5N-Bicalutamide | 5N-Bicalutamide is an androgen receptor (AR) antagonist with a Ki of 0.15 nM. 5N-Bicalutamide is a derivative of Bicalutamide (HY-14249). 5N-Bicalutamide reacts with Cys784 in the AR binding pocket via an activated aryl nitrile group to form a reversible thioimidate covalent adduct, which significantly enhances its binding affinity and inhibitory potency. 5N-Bicalutamide is used in prostate cancer-related research. | |||||||||||||||||||||
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