1877286-78-6
Chemical Structure
SG3-179
- CAS No.: 1877286-78-6
- Formula:C28H35ClFN7O3S
- Molecular Weight:604.14
IUPAC Name: 4-((4-((4-chloro-3-((1,1-dimethylethyl)sulfonamido)phenyl)amino)-5-methylpyrimidin-2-yl)amino)-2-fluoro-N-(1-methylpiperidin-4-yl)benzamide
InChIKey: RBZRCEPYYVFROZ-UHFFFAOYSA-N
SMILES: O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(C)C(NC4=CC=C(Cl)C(NS(=O)(C(C)(C)C)=O)=C4)=N3)C=C2F
Biological Activity: SG3-179 is a potent inhibitor against the BET bromodomain proteins. SG3-179 is also a JAK2 and FLT3 inhibitor. SG3-179 causes a rapid reduction in HOXB13 protein expression. SG3-179 is promising for research of multiple myeloma (MM1.S)[1][2].
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SG3-179 | SG3-179 is a potent inhibitor against the BET bromodomain proteins. SG3-179 is also a JAK2 and FLT3 inhibitor. SG3-179 causes a rapid reduction in HOXB13 protein expression. SG3-179 is promising for research of multiple myeloma (MM1.S). | |||||||||||||||||||||
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- [1]. Nerlakanti N, et al. Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer. Mol Cancer Ther. 2018 Dec;17(12):2796-2810. [Content Brief]
- [2]. Guan X. Discovery of Fluorescence Polarization Probes and Inhibitors for Testis-Specific Bromodomain and Extra-Terminal (BRDT) Proteins[J]. 2020.
Keywords
