1884226-20-3
1884226-20-3
Chemical Structure
Anticancer agent 124
- CAS No.: 1884226-20-3
- Formula:C26H21ClN4O3
- Molecular Weight:472.92
IUPAC Name: 5-((3-(5-(2-chlorophenyl)-1H-imidazol-2-yl)chroman-6-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
InChIKey: KPSFBIACWSYKON-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C(OC3=CC=C4C(CC(C5=NC=C(C6=CC=CC=C6Cl)N5)CO4)=C3)=CC=N2)CC1
Biological Activity: Anticancer agent 124 is an orally active, highly selective and potent pan RAF inhibitor. Anticancer agent 124 inhibits MAPK signalling in BRAF V600E, NRAS and KRAS mutant tumor cells[1].
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Anticancer agent 124 | Anticancer agent 124 is an orally active, highly selective and potent pan RAF inhibitor. Anticancer agent 124 inhibits MAPK signalling in BRAF V600E, NRAS and KRAS mutant tumor cells. | |||||||||||||||||||||
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References
Keywords
