188645-44-5
188645-44-5
Chemical Structure
LE-540
- CAS No.: 188645-44-5
- Formula:C33H32N2O2
- Molecular Weight:488.62
IUPAC Name: 4-(10,10,13,13,15-pentamethyl-11,12,13,15-tetrahydro-10H-dinaphtho[2,3-b:1',2'-e][1,4]diazepin-7-yl)benzoic acid
InChIKey: WJVKVKNDLOYKSA-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(C2=NC3=CC4=C(C(C)(C)CCC4(C)C)C=C3N(C)C5=C6C=CC=CC6=CC=C52)C=C1
Biological Activity: LE-540 is a selective retinoic acid receptor antagonist for RARβ (Ki=0.22 μM). LE-540 shows potential for use in cancer research, particularly for breast cancer and lung cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
LE-540 | 99.74% | LE-540 is a selective retinoic acid receptor antagonist for RARβ (Ki=0.22 μM). LE-540 shows potential for use in cancer research, particularly for breast cancer and lung cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Liu Y, et al. Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons. J Neurochem. 2008;106(3):1104-1116. [Content Brief]
- [2]. Neumann K, et al. Connecting liver and gut: murine liver sinusoidal endothelium induces gut tropism of CD4+ T cells via retinoic acid. Hepatology. 2012 Jun;55(6):1976-84. [Content Brief]
Keywords
