1886879-71-5
Chemical Structure
EM127
- CAS. Nr.: 1886879-71-5
- Formula:C14H18ClN3O3
- Molecular Weight:311.76
IUPAC Name: N-(1-(2-chloroacetyl)piperidin-4-yl)-5-cyclopropylisoxazole-3-carboxamide
InChIKey: OENTXAYVUCLRJQ-UHFFFAOYSA-N
SMILES: O=C(C1=NOC(C2CC2)=C1)NC3CCN(C(CCl)=O)CC3
Biological Activity: EM127 (compound 11c) is a SMYD3 covalent inhibitor with high selectivity, high affinity (KD=13 μM) and site-specificity. EM127 effectively inhibits ERK1/2 phosphorylation and reduces transcriptional regulation of SMYD3 target genes. EM127 effectively and prolongedly impairs methyltransferase activity. EM127 can be used in cancer research, particularly in SMYD3 positive tumours[1].
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EM127 | 99.94% | EM127 (compound 11c) is a SMYD3 covalent inhibitor with high selectivity, high affinity (KD=13 μM) and site-specificity. EM127 effectively inhibits ERK1/2 phosphorylation and reduces transcriptional regulation of SMYD3 target genes. EM127 effectively and prolongedly impairs methyltransferase activity. EM127 can be used in cancer research, particularly in SMYD3 positive tumours. | ||||||||||||||||||||
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