189275-71-6
189275-71-6
Chemical Structure
Ac-Trp-Glu-His-Asp-Aldehyde
- CAS No.: 189275-71-6
- Formula:C28H33N7O9
- Molecular Weight:611.60
InChIKey: ZSZYUXBVDPGGGX-QGQQZZQASA-N
SMILES: OC(C[C@@H](C=O)NC([C@H](CC1=CN=CN1)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O
Biological Activity: Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2].
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Ac-Trp-Glu-His-Asp-Aldehyde | Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM. | |||||||||||||||||||||
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References
- [1]. Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. [Content Brief]
- [2]. Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55. [Content Brief]
