1895861-88-7
Chemical Structure
MAY0132
- CAS No.: 1895861-88-7
- Formula:C16H15ClF3N
- Molecular Weight:313.75
IUPAC Name: N-(4-chloro-3-(trifluoromethyl)phenyl)-2,4,6-trimethylaniline
InChIKey: FLFWWGQQNBDVES-UHFFFAOYSA-N
SMILES: CC1=C(NC2=CC=C(Cl)C(C(F)(F)F)=C2)C(C)=CC(C)=C1
Biological Activity: MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. MAY0132 significantly inhibits replication of HMPV, AdV and RSV, reduces viral infection-induced cytokine/chemokine production, and inhibits NF-κB activation. MAY0132 has antiviral activity and can be used in the study of respiratory virus infection[1][2].
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MAY0132 | 99.93% | MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. MAY0132 significantly inhibits replication of HMPV, AdV and RSV, reduces viral infection-induced cytokine/chemokine production, and inhibits NF-κB activation. MAY0132 has antiviral activity and can be used in the study of respiratory virus infection. | ||||||||||||||||||||
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- [1]. Choi EJ, et al. Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections. Viruses. 2021 Jun 21;13(6):1179. [Content Brief]
- [2]. Wild CT, et al. Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors. ACS Med Chem Lett. 2016 Mar 28;7(5):460-4. [Content Brief]
Keywords
