197506-04-0
Chemical Structure
MEN-91507
- CAS No.: 197506-04-0
- Formula:C28H23FN4O3
- Molecular Weight:482.51
IUPAC Name: (E)-8-(4-(4-(4-fluorophenyl)butoxy)styryl)-2-(1H-tetrazol-5-yl)-4H-chromen-4-one
InChIKey: PYUGFOWNYMLROI-KPKJPENVSA-N
SMILES: O=C1C=C(C2=NN=NN2)OC3=C(/C=C/C4=CC=C(OCCCCC5=CC=C(F)C=C5)C=C4)C=CC=C13
Biological Activity: MEN-91507 is an orally activecysteinyl leukotriene receptor 1 (CysLTR1) receptor antagonist. MEN-91507 behaves as insurmountable antagonist of Leukotriene D4 (HY-113456)-induced calcium transients, with a pKb of 10.25. MEN-91507 can inhibit Leukotriene D4-induced bronchoconstriction and microvascular leakage in guinea-pigs. MEN-91507 can be used for the researches of inflammation, immunology[1].
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MEN-91507 | MEN-91507 is an orally activecysteinyl leukotriene receptor 1 (CysLTR1) receptor antagonist. MEN-91507 behaves as insurmountable antagonist of Leukotriene D4 (HY-113456)-induced calcium transients, with a pKb of 10.25. MEN-91507 can inhibit Leukotriene D4-induced bronchoconstriction and microvascular leakage in guinea-pigs. MEN-91507 can be used for the researches of inflammation, immunology. | |||||||||||||||||||||
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Keywords
