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Cat. No.: HY-113456

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Leukotriene D4

Name: Leukotriene D4
Brand: MedChemExpress
SKU: HY-113456
Price: 180.00 USD
Availability: InStock
Rating: 5 (3 reviews)

3 Cited Publications

고객리뷰

Based on 3 publication(s) in Google Scholar

Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.5%
CAS No.: 73836-78-9
화학식: C₂₅H₄₀N₂O₆S
분자량:496.66

보관:

Solution, -20°C, 2 years

Leukotriene D4 Chemical Structure

CAS No.: 73836-78-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vivo
- Clinical Trial
Chemical Information
Publications (3)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability^[1]^[2].

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	0.7 nM Compound: LTD4	Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins	[PMID: 23403082]
Sf9	IC₅₀	5.48 μM Compound: Leukotrien D4	TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells	[PMID: 11306690]

In Vivo

Leukotriene D4 (1.5, 3, 6, 12, 24 μg/paw; injected intradermally) causes edema and increases capillary permeability in a dose-related manner in mouse^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

21-24 g, Balb/c male mice^[2]
Dosage:

1.5, 3, 6, 12, 24 µg/paw
Administration:

Injected intradermally (10 µL was injected into the left hind paw)
Result:

Caused significant edematous response and dye extravasation at doses of 1.5-6 ~g/paw.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 73836-78-9
Appearance Liquid
분자량 496.66
화학식 C₂₅H₄₀N₂O₆S
Color Colorless to light yellow
SMILES

O=C(O)CNC([C@H](CS[C@@H]([C@@H](O)CCCC(O)=O)/C=C/C=C/C=C\C/C=C\CCCCC)N)=O
Structure Classification
- Others
Initial Source
- Endogenous metabolite
선적

Room temperature in continental US; may vary elsewhere.
보관

Solution, -20°C, 2 years

Publications (3)

All Cell Migration/Invasion AssayELISABio/Physico-chemical Assay

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Journal Impact Factor

Anal Chem

Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]

2025 May 13;97(18):9827-9835. PMID: 40302637
Cancer Cell Int

DPEP2 suppresses metastasis via NF-κB-mediated epithelial-mesenchymal transition and M2 polarization in p53-loss non-small cell lung cancer. [Abstract]

2025 Nov 17;25(1):408. PMID: 41250029

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

The transwell and wound healing analyses of Vector/DPEP2 cells cultured with M2 CM or LTD4 (Leukotriene D4, 100 nM, 48 h).

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

ELISA detected the level of LTD4 in the medium of M2 cocultured with Vector/DPEP2 cells.

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Total LTD4 levels in lung metastases.
Res Sq

2026 Mar 11.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (796 KB)
- English - EN (796 KB)
- Français - FR (796 KB)
- Deutsch - DE (796 KB)
- Norwegian - NO (796 KB)
- Español - ES (796 KB)
- Swedish - SV (796 KB)
- Italian - IT (796 KB)
- Korean - KR (796 KB)
- Portuguese - PT (796 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Smith LJ, et al. The effect of inhaled leukotriene D4 in humans. Am Rev Respir Dis. 1985 Mar;131(3):368-72. [Content Brief]

[2]. Griswold DE, et al. Phlogistic activity of leukotriene D4 in the mouse. Inflammation. 1986 Mar;10(1):1-7. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Leukotriene D4

3 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Publications (3)
순도&문서
References

1/16
1/16

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Customer Validation
The transwell and wound healing analyses of Vector/DPEP2 cells cultured with M2 CM or LTD4 (Leukotriene D4, 100 nM, 48 h).
1/16

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Customer Validation
ELISA detected the level of LTD4 in the medium of M2 cocultured with Vector/DPEP2 cells.
1/16

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Customer Validation
Total LTD4 levels in lung metastases.

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All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (3)

순도&문서

References

Calculators

Help & FAQs

Bioz

Leukotriene D4

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MK-571 sodium

12(S)-HETE

Atreleuton

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Publications Citing Use of MedChemExpress (MCE) Leukotriene D4

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (3)

순도&문서

References

Calculators

Help & FAQs

Leukotriene D4 Related Classifications

HY-113456 Related Classifications

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