1993176-75-2
Chemical Structure
N3-Gly-Gly-Gly-OH
- CAS 番号: 1993176-75-2
- Formula:C6H9N5O4
- Molecular Weight:215.17
IUPAC Name: (2-azidoacetyl)glycylglycine
InChIKey: JAMMEZNHAILDJV-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NCC(NCC(NCC(O)=O)=O)=O
Biological Activity: N3-Gly-Gly-Gly-OH is a oligo-Gly click chemistry reagent containing an azide group. Oligo-Gly also has been used as linker to combine different subunits of dimeric or oligomeric proteins or to create artificial multi-domain proteins. By modification into Gly-Gly-Gly-Ser motifs high solubility can be achieved[1][2][3]. N3-Gly-Gly-Gly-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N3-Gly-Gly-Gly-OH | 97.49% | N3-Gly-Gly-Gly-OH is a oligo-Gly click chemistry reagent containing an azide group. Oligo-Gly also has been used as linker to combine different subunits of dimeric or oligomeric proteins or to create artificial multi-domain proteins. By modification into Gly-Gly-Gly-Ser motifs high solubility can be achieved. N3-Gly-Gly-Gly-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | ||||||||||||||||||||
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- [1]. Imanishi M, et al. DNA-bending finger: artificial design of 6-zinc finger peptides with polyglycine linker and induction of DNA bending. Biochemistry. 2000 Apr 18;39(15):4383-90. [Content Brief]
- [2]. Tsygankova SV, et al. Biantennary oligoglycines and glyco-oligoglycines self-associating in aqueous medium. Beilstein J Org Chem. 2014 Jun 17;10:1372-82. [Content Brief]
- [3]. Hashii N, et al. [Site-specific O-Glycosylation Analysis of Therapeutic Fc-fusion Protein by Mass Spectrometry]. Yakugaku Zasshi. 2018;138(12):1483-1494. Japanese. [Content Brief]
Keywords
