1997387-43-5
1997387-43-5
Chemical Structure
PZM21
- CAS 番号: 1997387-43-5
- Formula:C19H27N3O2S
- Molecular Weight:361.50
IUPAC Name: 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
InChIKey: MEDBIJOVZJEMBI-YOEHRIQHSA-N
SMILES: O=C(N[C@@H](C)CC1=CSC=C1)NC[C@@H](N(C)C)CC2=CC=C(O)C=C2
Biological Activity: PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM[1][2][3].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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PZM21 | 99.87% | PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM. | ||||||||||||||||||||
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PZM21 (Standard) | ≥98% | PZM21 (Standard) is the analytical standard of PZM21 (HY-101386). This product is intended for research and analytical applications. PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM. | ||||||||||||||||||||
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References
- [1]. Manglik A, et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 Sep 8;537(7619):185-190. [Content Brief]
- [2]. Kostic M, et al. Biasing Opioid Receptors and Cholesterol as a Player in Developmental Biology. [Content Brief]
- [3]. Araldi D, et al. Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat. Neuroscience. 2018 Oct 17;394:60-71. [Content Brief]
Keywords
