2080332-70-1
Chemical Structure
SNOTRAP
- CAS No.: 2080332-70-1
- Formula:C37H46N3O6PS2
- Molecular Weight:723.88
IUPAC Name: S-(2-(diphenylphosphanyl)phenyl) 14-oxo-18-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-13-azaoctadecanethioate
InChIKey: CWQVJOHIKHFHOM-DGKNVMSKSA-N
SMILES: P(C1=C(SC(CCOCCOCCOCCNC(CCCC[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H])=O)=O)C=CC=C1)(C4=CC=CC=C4)C5=CC=CC=C5
Biological Activity: SNOTRAP (SNO trapping by triaryl phosphine) is a chemical probe used for detecting S-nitrosylated (SNO) proteins. SNOTRAP selectively converts S-nitrosylated cysteines in proteins into stable disulfide-iminophosphorane intermediates, which are then enriched with streptavidin and detected by nanoLC-MS/MS. SNOTRAP enables global enrichment and label-free quantification of SNO proteins and their modification sites in complex biological samples such as mouse brain tissues. SNOTRAP can be applied to studies related to nitrosative stress-associated diseases, including neurodegenerative diseases, cancer, and multiple sclerosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SNOTRAP | 99.02% | SNOTRAP (SNO trapping by triaryl phosphine) is a chemical probe used for detecting S-nitrosylated (SNO) proteins. SNOTRAP selectively converts S-nitrosylated cysteines in proteins into stable disulfide-iminophosphorane intermediates, which are then enriched with streptavidin and detected by nanoLC-MS/MS. SNOTRAP enables global enrichment and label-free quantification of SNO proteins and their modification sites in complex biological samples such as mouse brain tissues. SNOTRAP can be applied to studies related to nitrosative stress-associated diseases, including neurodegenerative diseases, cancer, and multiple sclerosis. | ||||||||||||||||||||
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- [1]. Yang H, et al. An improved sulfur-nitroso-proteome strategy for global profiling of sulfur-nitrosylated proteins and sulfur-nitrosylation sites in mice. Journal of chromatography. A. 2023 Aug 30;1705:464162. [Content Brief]
- [2]. Yang H, et al. Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3. Science advances. 2022 Dec 14;8(50):eade0764.
Keywords
