SNOTRAP
Based on 1 Customer Validation
SNOTRAP (SNO trapping by triaryl phosphine) is a chemical probe used for detecting S-nitrosylated (SNO) proteins. SNOTRAP selectively converts S-nitrosylated cysteines in proteins into stable disulfide-iminophosphorane intermediates, which are then enriched with streptavidin and detected by nanoLC-MS/MS. SNOTRAP enables global enrichment and label-free quantification of SNO proteins and their modification sites in complex biological samples such as mouse brain tissues. SNOTRAP can be applied to studies related to nitrosative stress-associated diseases, including neurodegenerative diseases, cancer, and multiple sclerosis.
For research use only. We do not sell to patients.
- Purity : 99.02%
- CAS No.: 2080332-70-1
- Formula: C37H46N3O6PS2
- Molecular Weight:723.88
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
SNOTRAP (1.5 mM; 2 h) efficiently labels endogenous S-nitrosylated proteins in mouse brain tissue (cortex, striatum, hippocampus) lysates, enabling the identification of 1181 SNO proteins (1714 SNO sites) with a specificity of 98%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2080332-70-1
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Appearance Solid
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Molecular Weight 723.88
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Formula C37H46N3O6PS2
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Color White to off-white
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SMILES
P(C1=C(SC(CCOCCOCCOCCNC(CCCC[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H])=O)=O)C=CC=C1)(C4=CC=CC=C4)C5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 103 mg/mL (142.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3814 mL | 6.9072 mL | 13.8144 mL | 34.5361 mL |
| 5 mM | 0.2763 mL | 1.3814 mL | 2.7629 mL | 6.9072 mL | |
| 10 mM | 0.1381 mL | 0.6907 mL | 1.3814 mL | 3.4536 mL | |
| 15 mM | 0.0921 mL | 0.4605 mL | 0.9210 mL | 2.3024 mL | |
| 20 mM | 0.0691 mL | 0.3454 mL | 0.6907 mL | 1.7268 mL | |
| 25 mM | 0.0553 mL | 0.2763 mL | 0.5526 mL | 1.3814 mL | |
| 30 mM | 0.0460 mL | 0.2302 mL | 0.4605 mL | 1.1512 mL | |
| 40 mM | 0.0345 mL | 0.1727 mL | 0.3454 mL | 0.8634 mL | |
| 50 mM | 0.0276 mL | 0.1381 mL | 0.2763 mL | 0.6907 mL | |
| 60 mM | 0.0230 mL | 0.1151 mL | 0.2302 mL | 0.5756 mL | |
| 80 mM | 0.0173 mL | 0.0863 mL | 0.1727 mL | 0.4317 mL | |
| 100 mM | 0.0138 mL | 0.0691 mL | 0.1381 mL | 0.3454 mL |
SNOTRAP Related Classifications
HY-D2902 Related Classifications
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