SNOTRAP 

SNOTRAP (S-nitrosylation trapping by triaryl phosphine) is a chemical probe for S-nitrosylated (SNO) proteins. SNOTRAP based proteomic pipeline can identify 1181 SNO proteins (1714 SNO sites) in the brain of mouse models. SNOTRAP can be used for nitrosative stress related diseases such as neurodegenerative disease, endotoxic shock, cancer, multiple sclerosis, and sickle cell disease^[1].

723.88

C₃₇H₄₆N₃O₆PS₂

2080332-70-1

Solid

White to off-white

P(C1=C(SC(CCOCCOCCOCCNC(CCCC[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H])=O)=O)C=CC=C1)(C4=CC=CC=C4)C5=CC=CC=C5

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Yang H, et al. An improved sulfur-nitroso-proteome strategy for global profiling of sulfur-nitrosylated proteins and sulfur-nitrosylation sites in mice. J Chromatogr A. 2023 Aug 30;1705:464162.  [Content Brief]