2102694-60-8
Chemical Structure
PROTAC Her3 Degrader-2
- CAS No.: 2102694-60-8
- Formula:C44H44Cl2N8O10
- Molecular Weight:915.77
IUPAC Name: N-(4-(4-(3-((3-cyano-4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinolin-7-yl)oxy)propyl)piperazin-1-yl)-4-oxobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
InChIKey: CYZJBFFFXNLVFF-UHFFFAOYSA-N
SMILES: N#CC1=CN=C2C=C(C(OC)=CC2=C1NC3=CC(OC)=C(C=C3Cl)Cl)OCCCN4CCN(CC4)C(CCCNC(COC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O)=O
Biological Activity: PROTAC Her3 Degrader-2 is a Her3 PROTAC degrader with an IC50 < 10 nM. PROTAC Her3 Degrader-2 recruits Her3 to E3 ubiquitin ligase to achieve selective degradation. PROTAC Her3 Degrader-2 can be used in the research of breast cancer, lung cancer, head and neck cancer, and prostate cancer[1].
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PROTAC Her3 Degrader-2 | PROTAC Her3 Degrader-2 is a Her3 PROTAC degrader with an IC50 < 10 nM. PROTAC Her3 Degrader-2 recruits Her3 to E3 ubiquitin ligase to achieve selective degradation. PROTAC Her3 Degrader-2 can be used in the research of breast cancer, lung cancer, head and neck cancer, and prostate cancer. | |||||||||||||||||||||
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