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Cat. No.: HY-103630

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PROTAC Her3 Degrader-2

PROTAC Her3 Degrader-2 is a Her3 PROTAC degrader with an IC₅₀ < 10 nM. PROTAC Her3 Degrader-2 recruits Her3 to E3 ubiquitin ligase to achieve selective degradation. PROTAC Her3 Degrader-2 can be used in the research of breast cancer, lung cancer, head and neck cancer, and prostate cancer.
(Pink: Her3 Target protein ligand; Blue: Cereblon ligand (HY-103597); Black: linker (HY-N0067)).

For research use only. We do not sell to patients.

CAS No.: 2102694-60-8
Formula: C₄₄H₄₄Cl₂N₈O₁₀
Molecular Weight:915.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC Her3 Degrader-2 Chemical Structure

CAS No.: 2102694-60-8

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC Her3 Degrader-2 is a Her3 PROTAC degrader with an IC₅₀ < 10 nM. PROTAC Her3 Degrader-2 recruits Her3 to E3 ubiquitin ligase to achieve selective degradation. PROTAC Her3 Degrader-2 can be used in the research of breast cancer, lung cancer, head and neck cancer, and prostate cancer^[1]. (Pink: Her3 Target protein ligand; Blue: Cereblon ligand (HY-103597); Black: linker (HY-N0067)).

IC₅₀ & Target

^[1]

HER3

All PROTACs Isoforms :

All EGFR Isoforms :

In Vitro

PROTAC Her3 Degrader-2 (Compound CY2) exhibits extremely potent target kinase binding activity in vitro, with an IC₅₀ < 10 nM^[1].
PROTAC Her3 Degrader-2 exhibits no significant Her3 protein degradation in PC9-GR4 or Ovacar 8 cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

PC9-GR4 and Ovacar 8 cells
Concentration:

2 μM
Incubation Time:

4, 8 h
Result:

Did not exhibit significant Her3 protein degradation.

Chemical Information

CAS No. 2102694-60-8
Molecular Weight 915.77
Formula C₄₄H₄₄Cl₂N₈O₁₀
SMILES

N#CC1=CN=C2C=C(C(OC)=CC2=C1NC3=CC(OC)=C(C=C3Cl)Cl)OCCCN4CCN(CC4)C(CCCNC(COC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2017117474A1. WIPO. 2017-07-06.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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