2113664-14-3
Chemical Structure
UKH-1114
- CAS No.: 2113664-14-3
- Formula:C22H24F3NO
- Molecular Weight:375.43
IUPAC Name: 3-(9-(4-(trifluoromethyl)phenyl)-3,4,5,6-tetrahydro-1,6-methanobenzo[c]azocin-2(1H)-yl)propan-1-ol
InChIKey: ONAFBVDWEXCSIP-UHFFFAOYSA-N
SMILES: OCCCN1CCCC2C3=CC=C(C4=CC=C(C(F)(F)F)C=C4)C=C3C1C2
Biological Activity: UKH-1114 is a selective TMEM97 (a sigma-2 receptor) agonist with a Ki values of 1279 and 46 nM for σ1R and σ2R/TMEM97, respectively. UKH-1114 exhibits exceptional selectivity with negligible affinity for over 50 other receptors and channels. UKH-1114 effectively relieves spared nerve injury (SNI)-induced mechanical hypersensitivity with a long-lasting duration and without motor impairment. UKH-1114 can be used for neuropathic pain research[1].
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UKH-1114 | 99.88% | UKH-1114 is a selective TMEM97 (a sigma-2 receptor) agonist with a Ki values of 1279 and 46 nM for σ1R and σ2R/TMEM97, respectively. UKH-1114 exhibits exceptional selectivity with negligible affinity for over 50 other receptors and channels. UKH-1114 effectively relieves spared nerve injury (SNI)-induced mechanical hypersensitivity with a long-lasting duration and without motor impairment. UKH-1114 can be used for neuropathic pain research. | ||||||||||||||||||||
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