2119725-22-1
Chemical Structure
Plecstatin-1
- CAS No.: 2119725-22-1
- Formula:C22H23Cl2FN2RuS
- Molecular Weight:538.47
InChIKey: TXBPOTKGRCTAAD-UHFFFAOYSA-L
SMILES: [Cl-][Ru+2]12345([CH]6=[CH]47)([N]8=CC=CC=C8C(NC(C=C9)=CC=C9F)=[S]5)[C]6(C(C)C)=[CH]1[CH]2=[C]37C.[Cl-]
Biological Activity: Plecstatin‑1 is a metal complex that drives the aggregation and collapse of the plectin network, and disrupts the cytoskeletal structures of α‑tubulin and F‑actin. Plecstatin-1 triggers oxidative stress, mediates the phosphorylation of eIF2α, and induces molecular features associated with immunogenic cell death, including calreticulin membrane exposure, membrane localization of HSP70/HSP90, ATP secretion, and HMGB‑1 release. Plecstatin-1 induces apoptosis via the intrinsic mitochondrial pathway and exerts anti-invasive activity. Plecstatin‑1 inhibits sphere proliferation and reduces clonogenicity in the 3D tumor spheroid model of colon cancer cells. Plecstatin-1 is applicable to relevant research on colorectal cancer[1].
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Plecstatin-1 | Plecstatin‑1 is a metal complex that drives the aggregation and collapse of the plectin network, and disrupts the cytoskeletal structures of α‑tubulin and F‑actin. Plecstatin-1 triggers oxidative stress, mediates the phosphorylation of eIF2α, and induces molecular features associated with immunogenic cell death, including calreticulin membrane exposure, membrane localization of HSP70/HSP90, ATP secretion, and HMGB‑1 release. Plecstatin-1 induces apoptosis via the intrinsic mitochondrial pathway and exerts anti-invasive activity. Plecstatin‑1 inhibits sphere proliferation and reduces clonogenicity in the 3D tumor spheroid model of colon cancer cells. Plecstatin-1 is applicable to relevant research on colorectal cancer. | |||||||||||||||||||||
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Keywords
