2131126-33-3
2131126-33-3
Chemical Structure
Deulorlatinib
Synonym(s): PF-06463922-d3-1
- CAS No.: 2131126-33-3
- Formula:C21H16D3FN6O2
- Molecular Weight:409.43
InChIKey: IIXWYSCJSQVBQM-LMUHODJSSA-N
SMILES: N#CC1=C2C3=CN=C(N)C(O[C@@H](C4=CC(F)=CC=C4C(N(CC2=NN1C([2H])([2H])[2H])C)=O)C)=C3
Biological Activity: Deulorlatinib (compound A), a deuterated derivative of Lorlatinib (HY-12215), is a potent inhibitor of tyrosine kinase demonstrating the potential for the research of ALK-positive advanced NSCLC[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Deulorlatinib | 99.84% | Deulorlatinib (compound A), a deuterated derivative of Lorlatinib (HY-12215), is a potent inhibitor of tyrosine kinase demonstrating the potential for the research of ALK-positive advanced NSCLC. | ||||||||||||||||||||
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Lorlatinib (Standard) | 99.92% | Lorlatinib (Standard) is the analytical standard of Lorlatinib. This product is intended for research and analytical applications. Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM (ALKL1196), 14-80 nM (ALKG1269A), 38-50 nM (ALK1151Tins), 77-113 nM (ALKG1202R), respectively. | ||||||||||||||||||||
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Lorlatinib | 99.99% | Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM (ALKL1196), 14-80 nM (ALKG1269A), 38-50 nM (ALK1151Tins), 77-113 nM (ALKG1202R), respectively. | ||||||||||||||||||||
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References
