2143104-16-7
Chemical Structure
EGFR T790M/FAK-IN-1
- CAS No.: 2143104-16-7
- Formula:C26H30ClN7O3
- Molecular Weight:524.02
IUPAC Name: 2-((5-chloro-2-((3-methyl-4-(2-morpholinoacetamido)phenyl)amino)pyrimidin-4-yl)amino)-N-ethylbenzamide
InChIKey: URNRHTHWCVYNOA-UHFFFAOYSA-N
SMILES: O=C(NCC)C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC3=CC=C(NC(=O)CN4CCOCC4)C(=C3)C
Biological Activity: EGFR T790M/FAK-IN-1 is a dual inhibitor of EGFRT790M and FAK, with an IC50 of 99.1 nM against EGFRT790M and an IC50 of 117.7 nM against FAK. EGFR T790M/FAK-IN-1 can be used for research on pancreatic cancer, drug-resistant breast cancer, and drug-resistant lung cancer[1].
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EGFR T790M/FAK-IN-1 | EGFR T790M/FAK-IN-1 is a dual inhibitor of EGFRT790M and FAK, with an IC50 of 99.1 nM against EGFRT790M and an IC50 of 117.7 nM against FAK. EGFR T790M/FAK-IN-1 can be used for research on pancreatic cancer, drug-resistant breast cancer, and drug-resistant lung cancer. | |||||||||||||||||||||
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