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Cat. No.: HY-183123

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EGFR T790M/FAK-IN-1

EGFR T790M/FAK-IN-1 is a dual inhibitor of EGFR^T790M and FAK, with an IC₅₀ of 99.1 nM against EGFR^T790M and an IC₅₀ of 117.7 nM against FAK. EGFR T790M/FAK-IN-1 can be used for research on pancreatic cancer, drug-resistant breast cancer, and drug-resistant lung cancer.

For research use only. We do not sell to patients.

CAS No.: 2143104-16-7
Formula: C₂₆H₃₀ClN₇O₃
Molecular Weight:524.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR T790M/FAK-IN-1 Chemical Structure

CAS No.: 2143104-16-7

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One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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References
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Biological Activity

Description

IC₅₀ & Target

^[1]

EGFR^T790M

99.1 nM (IC₅₀)

All EGFR Isoforms :

In Vitro

EGFR^T790M/FAK-IN-1 (Compound 9g) (1.25-40 μM; 72 h) inhibits AsPC-1 pancreatic cancer cell proliferation with an IC₅₀ of 1.882 μM^[1].
EGFR^T790M/FAK-IN-1 (Compound 9g) (1.25-40 μM; 72 h) inhibits BxPC-3 pancreatic cancer cell proliferation with an IC₅₀ of 1.947 μM^[1].
EGFR^T790M/FAK-IN-1 (Compound 9g) (1.25-40 μM; 72 h) inhibits Panc-1 pancreatic cancer cell proliferation with an IC₅₀ of 1.787 μM^[1].
EGFR^T790M/FAK-IN-1 (Compound 9g) (1.25-40 μM; 72 h) inhibits Hpde6-c7 normal human pancreatic ductal cell proliferation with an IC₅₀ of 2.066 μM^[1].
EGFR^T790M/FAK-IN-1 (Compound 9g) (1.25-40 μM; 72 h) inhibits MCF-7/adr drug-resistant breast cancer cell proliferation with an IC₅₀ of 0.716 μM^[1].
EGFR^T790M/FAK-IN-1 (Compound 9g) (1.25-40 μM; 72 h) inhibits H1975 drug-resistant lung cancer cell proliferation with an IC₅₀ of 0.513 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2143104-16-7
Molecular Weight 524.02
Formula C₂₆H₃₀ClN₇O₃
SMILES

O=C(NCC)C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC3=CC=C(NC(=O)CN4CCOCC4)C(=C3)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ai M, et al. Design and synthesis of diphenylpyrimidine derivatives (DPPYs) as potential dual EGFR T790M and FAK inhibitors against a diverse range of cancer cell lines. Bioorg Chem. 2020 Jan;94:103408.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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