2146132-73-0
2146132-73-0
Chemical Structure
OATD-02
- CAS No.: 2146132-73-0
- Formula:C12H25BN2O4
- Molecular Weight:272.15
InChIKey: NZNAXQBYXLSQHO-JBLDHEPKSA-N
SMILES: N[C@]1(C(O)=O)C[C@H](CCB(O)O)CC[C@H]1CN(C)C
Biological Activity: OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study[1].
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OATD-02 | OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study. | |||||||||||||||||||||
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References
Keywords
