216058-27-4
Chemical Structure
SB-272183
- CAS No.: 216058-27-4
- Formula:C29H28ClN5O
- Molecular Weight:498.02
IUPAC Name: 5-chloro-6-(4-methylpiperazin-1-yl)-N-(4-(pyridin-4-yl)naphthalen-1-yl)indoline-1-carboxamide
InChIKey: DAPBIPAGJXKFCI-UHFFFAOYSA-N
SMILES: O=C(N1C2=CC(N3CCN(CC3)C)=C(C=C2CC1)Cl)NC4=C5C=CC=CC5=C(C6=CC=NC=C6)C=C4
Biological Activity: SB-272183 is a selective 5-HT1A, 5-HT1B and 5-HT1D receptor antagonist. In addition, SB-272183 is also a potent and selective ligand for 5-HT1A, 5-HT1B and 5-HT1D receptors in human recombinant and native tissues with pKi values of 8.0, 8.1 and 8.7, respectively. SB-272183 can be used in antidepressant research[1].
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SB-272183 | SB-272183 is a selective 5-HT1A, 5-HT1B and 5-HT1D receptor antagonist. In addition, SB-272183 is also a potent and selective ligand for 5-HT1A, 5-HT1B and 5-HT1D receptors in human recombinant and native tissues with pKi values of 8.0, 8.1 and 8.7, respectively. SB-272183 can be used in antidepressant research. | |||||||||||||||||||||
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Keywords
