2170142-58-0
Chemical Structure
(S)-GSK-3685032
- CAS No.: 2170142-58-0
- Formula:C22H24N6OS
- Molecular Weight:420.53
IUPAC Name: (S)-2-((6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl)thio)-2-phenylacetamide
InChIKey: KNKHRZYILDZLRE-IBGZPJMESA-N
SMILES: N#CC1=C(N2CCC(CC2)N)N=C(C(C#N)=C1CC)S[C@@H](C3=CC=CC=C3)C(N)=O
Biological Activity: (S)-GSK-3685032 is the isomer of GSK-3685032 (HY-139664), and can be used as an experimental control. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
(S)-GSK-3685032 | 98.82% | (S)-GSK-3685032 is the isomer of GSK-3685032 (HY-139664), and can be used as an experimental control. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
