2181774-46-7
Chemical Structure
4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium
Synonym(s): 4-MU-α-idoa 2-sulfate sodium
- CAS No.: 2181774-46-7
- Formula:C16H14Na2O12S
- Molecular Weight:476.32
IUPAC Name: sodium (2R,3S,4S,5R,6S)-3,4-dihydroxy-6-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)-5-(sulfonatooxy)tetrahydro-2H-pyran-2-carboxylate
InChIKey: BGWMBPGUPUSUIU-CEWNINSASA-L
SMILES: O=S(O[C@H]([C@H]([C@@H]([C@@H](O1)C(O[Na])=O)O)O)[C@@H]1OC2=CC=C(C(C)=CC(O3)=O)C3=C2)(O[Na])=O
Biological Activity: 4-Methylumbelliferyl-α-L-iduronide 2-sulfate (4-MU-α-idoa 2-sulfate) sodium is a fluorogenic substrate of iduronate-2-sulfatase (I2S). 4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium can be hydrolyzed by lysosomal enzyme α-l-iduronidase (IDUA) and release the fluorophore 4-Methylumbelliferone (HY-N0187). 4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium can be used to detect Hurler syndrome[1][2].
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4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium | 98.77% | 4-Methylumbelliferyl-α-L-iduronide 2-sulfate (4-MU-α-idoa 2-sulfate) sodium is a fluorogenic substrate of iduronate-2-sulfatase (I2S). 4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium can be hydrolyzed by lysosomal enzyme α-l-iduronidase (IDUA) and release the fluorophore 4-Methylumbelliferone (HY-N0187). 4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium can be used to detect Hurler syndrome. | ||||||||||||||||||||
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- [1]. Azadeh M, et al. A Rapid Two-Step Iduronate-2-Sulfatatse Enzymatic Activity Assay for MPSII Pharmacokinetic Assessment. JIMD Rep. 2018;38:89-95. [Content Brief]
- [2]. Gusarova VD, et al. Characterization of a HIR-Fab-IDS, Novel Iduronate 2-Sulfatase Fusion Protein for the Treatment of Neuropathic Mucopolysaccharidosis Type II (Hunter Syndrome). BioDrugs. 2023 May;37(3):375-395. [Content Brief]
