2244884-08-8
2244884-08-8
Chemical Structure
RTI-13951-33
- CAS No.: 2244884-08-8
- Formula:C28H33N3O3
- Molecular Weight:459.58
IUPAC Name: (1R,2R)-N-((2R,3R)-2-amino-3-methoxybutyl)-N-(4'-(methoxymethyl)-[1,1'-biphenyl]-4-yl)-2-(pyridin-2-yl)cyclopropane-1-carboxamide
InChIKey: XCHHIKJEGXHKLQ-UJTWYAIMSA-N
SMILES: COCC1=CC=C(C2=CC=C(N(C[C@@H](N)[C@@H](C)OC)C([C@H]3[C@H](C4=CC=CC=N4)C3)=O)C=C2)C=C1
Biological Activity: RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 reduces alcohol reinforcement and intake behaviors in rats[1].
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RTI-13951-33 | RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 reduces alcohol reinforcement and intake behaviors in rats. | |||||||||||||||||||||
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