2245791-50-6
2245791-50-6
Chemical Structure
OTB-658
- CAS No.: 2245791-50-6
- Formula:C17H20FN3O4S
- Molecular Weight:381.42
InChIKey: WZAVWVAEARSISR-HOCLYGCPSA-N
SMILES: O=C1N2C3=CC(F)=C(N4CCSCC4)C=C3OC[C@@]2([H])[C@@H](O1)CNC(C)=O
Biological Activity: OTB-658 is a conformationally restricted oxazolidinone antibacterial candidate that exhibits bacteriostatic activity against Mycobacterium tuberculosis. OTB-658 enters macrophages and inhibits intracellular M. tuberculosis growth. OTB-658 exhibits dose-dependent antibacterial activity. OTB-658 is used in research related to tuberculosis and drug-resistant tuberculosis[1][2].
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OTB-658 | OTB-658 is a conformationally restricted oxazolidinone antibacterial candidate that exhibits bacteriostatic activity against Mycobacterium tuberculosis. OTB-658 enters macrophages and inhibits intracellular M. tuberculosis growth. OTB-658 exhibits dose-dependent antibacterial activity. OTB-658 is used in research related to tuberculosis and drug-resistant tuberculosis. | |||||||||||||||||||||
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References
- [1]. Guo S, et al. In Vitro and In Vivo Activity of Oxazolidinone Candidate OTB-658 against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0097421.
- [2]. Liu H, et al. Efficacy of Replacing Linezolid with OTB-658 in Anti-Tuberculosis Regimens in Murine Models. Antimicrobial agents and chemotherapy. 2023 Feb 16;67(2):e0139922.
