2253119-24-1
Chemical Structure
KRAS G12C inhibitor 47
- CAS No.: 2253119-24-1
- Formula:C30H28ClFN4O3
- Molecular Weight:547.02
IUPAC Name: 4-(4-acryloylpiperazin-1-yl)-6-chloro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropylphenyl)quinazolin-2(1H)-one
InChIKey: AFCLJUXYULJJII-UHFFFAOYSA-N
SMILES: O=C1N=C(N2CCN(CC2)C(C=C)=O)C3=C(N1C4=C(C(C)C)C=CC=C4)C=C(C5=C(O)C=CC=C5F)C(Cl)=C3
Biological Activity: KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 µM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 µM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
KRAS G12C inhibitor 47 | KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 µM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 µM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
