2267306-14-7
Chemical Structure
Pomalidomide-PEG2-azide
- CAS No.: 2267306-14-7
- Formula:C19H20N6O7
- Molecular Weight:444.40
IUPAC Name: 2-(2-(2-azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide
InChIKey: QMQAWNMGKYQDLT-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCN=[N+]=[N-]
Biological Activity: Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Pomalidomide-PEG2-azide | 96.59% | Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | ||||||||||||||||||||
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Similarity Score 0.94
HY-137538Pomalidomide-PEG3-azide -
Similarity Score 0.92
HY-133138Pomalidomide-PEG1-azide -
Similarity Score 0.89
HY-138858Thalidomide-amido-PEG2-NH2 -
Similarity Score 0.89
HY-138858AThalidomide-amido-PEG2-NH2 hydrochloride -
Similarity Score 0.86
HY-133817APomalidomide-amino-PEG3-NH2 -
Similarity Score 0.86
HY-132208Pomalidomide 4'-PEG2-azide -
Similarity Score 0.85
HY-133817Pomalidomide-amino-PEG3-NH2 hydrochloride -
Similarity Score 0.83
HY-136772Pomalidomide-PEG1-NH2 hydrochloride -
Similarity Score 0.83
HY-163647Lenalidomide-COCH-PEG2-azido -
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