2272975-74-1
2272975-74-1
Chemical Structure
Sefaxersen
Synonym(s): IONIS-FB-LRx; RG6299; ISIS 696844
- CAS No.: 2272975-74-1
- Formula:N/A
- Molecular Weight:9056.30
IUPAC Name: N2-(tert-butoxycarbonyl)-N6-diazo-L-lysine
SMILES: [Sefaxersen]
Biological Activity: Sefaxersen (IONIS-FB-LRx) is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). Sefaxersen effectively reduces circulating levels of CFB. Sefaxersen can be used for geographic atrophy (GA) research[1][2].
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Sefaxersen | 99.46% | Sefaxersen (IONIS-FB-LRx) is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). Sefaxersen effectively reduces circulating levels of CFB. Sefaxersen can be used for geographic atrophy (GA) research. | ||||||||||||||||||||
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References
- [1]. Dreismann AK, et al. Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway. Immunol Rev. 2022 Nov 12. [Content Brief]
- [2]. Mahmoudzadeh R, et al. Emerging treatments for geographic atrophy in age-related macular degeneration. Curr Opin Ophthalmol. 2021 May 1;32(3):294-300. [Content Brief]
