2300178-76-9
Chemical Structure
Moricizine-d8 Hydrochloride
Synonym(s): EN 313-d8;Ethmozin-d8;Moracizine-d8
- CAS No.: 2300178-76-9
- Formula:C22H18D8ClN3O4S
- Molecular Weight:472.03
IUPAC Name: ethyl (10-(3-(morpholino-d8)propanoyl)-10H-phenothiazin-2-yl)carbamate hydrochloride
InChIKey: GAQAKFHSULJNAK-USILMEKGSA-N
SMILES: [2H]C1([2H])C([2H])([2H])OC([2H])([2H])C([2H])([2H])N1CCC(N2C3=CC(NC(OCC)=O)=CC=C3SC4=CC=CC=C42)=O.Cl
Biological Activity: Moricizine-d8 Hydrochloride is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1][2].
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Moricizine-d8 Hydrochloride | 99.61% | Moricizine-d8 Hydrochloride is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period. | ||||||||||||||||||||
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Moricizine Hydrochloride | 98.0% | Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Bigger JT Jr. Cardiac electrophysiologic effects of moricizine hydrochloride. Am J Cardiol. 1990 Feb 20;65(8):15D-20D; discussion 68D-71D. [Content Brief]
